15 February 2012 High-speed CMOS image sensor for high-throughput lensless microfluidic imaging system
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The integration of CMOS image sensor and microfluidics becomes a promising technology for point-of-care (POC) diagnosis. However, commercial image sensors usually have limited speed and low-light sensitivity. One high-speed and high-sensitivity CMOS image sensor chip is introduced in this paper, targeted for high-throughput microfluidic imaging system. Firstly, high speed image sensor architecture is introduced with design of column-parallel single-slope analog-todigital converter (ADC) with digital correlated double sampling (CDS). The frame rate can be achieved to 2400 frames/second (fps) with resolution of 128×96 for high-throughput microfluidic imaging. Secondly, the designed system has superior low-light sensitivity, which is achieved by large pixel size (10μm×10μm, 56% fill factor). Pixel peak signalnoise- ratio (SNR) reaches to 50dB with 10dB improvement compared to the commercial pixel (2.2μm×2.2μm). The degradation of pixel resolution is compensated by super-resolution image processing algorithm. By reconstructing single image with multiple low-resolution frames, we can equivalently achieve 2μm resolution with physical 10μm pixel. Thirdly, the system-on-chip (SoC) integration results in a real-time controlled intelligent imaging system without expensive data storage and time-consuming computer analysis. This initial sensor prototype with timing-control makes it possible to develop high-throughput lensless microfluidic imaging system for POC diagnosis.
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Mei Yan, Mei Yan, Xiwei Huang, Xiwei Huang, Qixiang Jia, Qixiang Jia, Revanth Nadipalli, Revanth Nadipalli, Tongxi Wang, Tongxi Wang, Yang Shang, Yang Shang, Hao Yu, Hao Yu, Minkyu Je, Minkyu Je, Kiatseng Yeo, Kiatseng Yeo, } "High-speed CMOS image sensor for high-throughput lensless microfluidic imaging system", Proc. SPIE 8298, Sensors, Cameras, and Systems for Industrial and Scientific Applications XIII, 829804 (15 February 2012); doi: 10.1117/12.911962; https://doi.org/10.1117/12.911962


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