3 March 2012 Spectrum optimization of a Talbot-Lau interferometer towards clinical application
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Abstract
X-ray phase-contrast imaging (XPCI) using a Talbot-Lau interferometer is a promising modality to increase soft-tissue contrast in medical imaging and has drawn the attention of many groups worldwide. Nevertheless, due to the many free parameters to be optimized in a XPCI setup, there's a long way to go to find the optimal geometry, design energy and spectrum for a future clinical application. In this contribution, we present a fast procedure to optimize the visibility response of a Talbot-Lau Interferometer with respect to an introduced filter material. This is done by performing a virtual filtering of the known reference tube spectrum, followed by calculating the visibility using the simulated detector and interferometer responses. Additionally, our procedure can also be used to optimize the general setup lengths, the grating properties or the design energy. We present recent results of the optimization process of our lab setup, where the simulations predict a visibility increase of approximately 72% compared to the non-optimized state. In the future, we are going to extend the functionality of our optimization algorithm to perform simulations that allow the prediction of best suitable spectrum for a given application at a certain noise level tolerated and at the lowest dose possible.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Thomas Weber, Thomas Weber, Florian Bayer, Florian Bayer, Karl Gödel, Karl Gödel, Wilhelm Haas, Wilhelm Haas, Georg Pelzer, Georg Pelzer, Jens Rieger, Jens Rieger, André Ritter, André Ritter, Lukas Wucherer, Lukas Wucherer, Jürgen Durst, Jürgen Durst, Thilo Michel, Thilo Michel, Gisela Anton, Gisela Anton, } "Spectrum optimization of a Talbot-Lau interferometer towards clinical application", Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 83135F (3 March 2012); doi: 10.1117/12.911321; https://doi.org/10.1117/12.911321
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