Spectrum optimization of a Talbot-Lau interferometer towards clinical application

Thomas Weber; Florian Bayer; Karl Gödel; Wilhelm Haas; Georg Pelzer; Jens Rieger; André Ritter; Lukas Wucherer; Jürgen Durst; Thilo Michel; Gisela Anton

doi:10.1117/12.911321

3 March 2012 Spectrum optimization of a Talbot-Lau interferometer towards clinical application

Thomas Weber, Florian Bayer, Karl Gödel, Wilhelm Haas, Georg Pelzer, Jens Rieger, André Ritter, Lukas Wucherer, Jürgen Durst, Thilo Michel, Gisela Anton

Author Affiliations +

Proceedings Volume 8313, Medical Imaging 2012: Physics of Medical Imaging; 83135F (2012) https://doi.org/10.1117/12.911321
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

X-ray phase-contrast imaging (XPCI) using a Talbot-Lau interferometer is a promising modality to increase soft-tissue contrast in medical imaging and has drawn the attention of many groups worldwide. Nevertheless, due to the many free parameters to be optimized in a XPCI setup, there's a long way to go to find the optimal geometry, design energy and spectrum for a future clinical application. In this contribution, we present a fast procedure to optimize the visibility response of a Talbot-Lau Interferometer with respect to an introduced filter material. This is done by performing a virtual filtering of the known reference tube spectrum, followed by calculating the visibility using the simulated detector and interferometer responses. Additionally, our procedure can also be used to optimize the general setup lengths, the grating properties or the design energy. We present recent results of the optimization process of our lab setup, where the simulations predict a visibility increase of approximately 72% compared to the non-optimized state. In the future, we are going to extend the functionality of our optimization algorithm to perform simulations that allow the prediction of best suitable spectrum for a given application at a certain noise level tolerated and at the lowest dose possible.

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Thomas Weber, Florian Bayer, Karl Gödel, Wilhelm Haas, Georg Pelzer, Jens Rieger, André Ritter, Lukas Wucherer, Jürgen Durst, Thilo Michel, and Gisela Anton "Spectrum optimization of a Talbot-Lau interferometer towards clinical application", Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 83135F (3 March 2012); https://doi.org/10.1117/12.911321

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