X-ray phase-contrast imaging (XPCI) using a Talbot-Lau interferometer is a promising modality to increase
soft-tissue contrast in medical imaging and has drawn the attention of many groups worldwide. Nevertheless,
due to the many free parameters to be optimized in a XPCI setup, there's a long way to go to find the optimal
geometry, design energy and spectrum for a future clinical application.
In this contribution, we present a fast procedure to optimize the visibility response of a Talbot-Lau Interferometer
with respect to an introduced filter material. This is done by performing a virtual filtering of the
known reference tube spectrum, followed by calculating the visibility using the simulated detector and interferometer
responses. Additionally, our procedure can also be used to optimize the general setup lengths, the grating
properties or the design energy.
We present recent results of the optimization process of our lab setup, where the simulations predict a visibility
increase of approximately 72% compared to the non-optimized state.
In the future, we are going to extend the functionality of our optimization algorithm to perform simulations
that allow the prediction of best suitable spectrum for a given application at a certain noise level tolerated and
at the lowest dose possible.