DynAMITe: a prototype large area CMOS APS for breast cancer diagnosis using x-ray diffraction measurements

A. Konstantinidis; T. Anaxagoras; M. Esposito; N. Allinson; R. Speller

doi:10.1117/12.911541

9 March 2012 DynAMITe: a prototype large area CMOS APS for breast cancer diagnosis using x-ray diffraction measurements

A. Konstantinidis, T. Anaxagoras, M. Esposito, N. Allinson, R. Speller

Proceedings Volume 8313, Medical Imaging 2012: Physics of Medical Imaging; 83135H (2012) https://doi.org/10.1117/12.911541
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

X-ray diffraction studies are used to identify specific materials. Several laboratory-based x-ray diffraction studies were made for breast cancer diagnosis. Ideally a large area, low noise, linear and wide dynamic range digital x-ray detector is required to perform x-ray diffraction measurements. Recently, digital detectors based on Complementary Metal-Oxide- Semiconductor (CMOS) Active Pixel Sensor (APS) technology have been used in x-ray diffraction studies. Two APS detectors, namely Vanilla and Large Area Sensor (LAS), were developed by the Multidimensional Integrated Intelligent Imaging (MI-3) consortium to cover a range of scientific applications including x-ray diffraction. The MI-3 Plus consortium developed a novel large area APS, named as Dynamically Adjustable Medical Imaging Technology (DynAMITe), to combine the key characteristics of Vanilla and LAS with a number of extra features. The active area (12.8 × 13.1 cm²) of DynaMITe offers the ability of angle dispersive x-ray diffraction (ADXRD). The current study demonstrates the feasibility of using DynaMITe for breast cancer diagnosis by identifying six breast-equivalent plastics. Further work will be done to optimize the system in order to perform ADXRD for identification of suspicious areas of breast tissue following a conventional mammogram taken with the same sensor.

Citation Download Citation

A. Konstantinidis, T. Anaxagoras, M. Esposito, N. Allinson, and R. Speller "DynAMITe: a prototype large area CMOS APS for breast cancer diagnosis using x-ray diffraction measurements", Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 83135H (9 March 2012); https://doi.org/10.1117/12.911541

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