Low-frequency pathophysiological characteristics of pediatric epileptic cortex during the interictal period detected using a dual-wavelength imaging system

Yinchen Song; Po-Ching Chen; Sanjiv Bhatia; John Ragheb; Prasanna Jayakar; Wei-Chiang Lin

doi:10.1117/12.911031

5 April 2012 Low-frequency pathophysiological characteristics of pediatric epileptic cortex during the interictal period detected using a dual-wavelength imaging system

Yinchen Song, Po-Ching Chen, Sanjiv Bhatia, John Ragheb, Prasanna Jayakar, Wei-Chiang Lin

Author Affiliations +

Proceedings Volume 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging; 83170V (2012) https://doi.org/10.1117/12.911031
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

In this pilot study, we explored the potential of using a diffuse reflectance imaging system to extract interictal pathophysiological characteristics of epileptic cortex in an intraoperative setting. The imaging system was able to simultaneously measure diffuse reflectance signals at two distinct wavelengths (500 and 700 nm) from the entire exposed cortical surface. It was used to study ten pediatric patients during their epilepsy surgery. Diffuse reflectance images, Rd(x,y,λ,t) at 500 nm and 700 nm, were acquired at a 5 Hz rate for at least 200 seconds. Post imaging analysis identified a unique local frequency oscillation (LFO), below respiration rate, existed in Rd(x,y,500 nm,t) and Rd(x,y,700 nm,t). Mapping the spectral densities of LFOs over the cortical surface identified the spatial distribution of the LFOs. In almost all ten patients studied, the location demonstrating strong LFOs coincided with the epileptic cortex determined using ECoG. However, some LFOs were found in close proximity to functional areas according to fMRI. We further used the correlation coefficient map to identify those pixels with similar waveforms for better demarcation. These preliminary results support the feasibility of using wavelength-dependent diffuse reflectance imaging to intra-operatively detect epileptic cortex.

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Yinchen Song, Po-Ching Chen, Sanjiv Bhatia, John Ragheb, Prasanna Jayakar, and Wei-Chiang Lin "Low-frequency pathophysiological characteristics of pediatric epileptic cortex during the interictal period detected using a dual-wavelength imaging system", Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83170V (5 April 2012); https://doi.org/10.1117/12.911031

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