16 April 2012 Magnetic resonance guided optical spectroscopy imaging of human breast cancer using a combined frequency domain and continuous wave approach
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Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is used to image high-risk patients for breast cancer because of its higher sensitivity to tumors (approaching 100%) than traditional x-ray mammography. We focus on Near Infrared Spectroscopy (NIRS) as an emerging functional and molecular imaging technique that non-invasively quantifies optical properties of total hemoglobin, oxygen saturation, water content, scattering, and lipid concentration to increase the relatively low specificity of DCE-MRI. Our optical imaging system combines six frequency domain wavelengths, measured using PMT detectors with three continuous wave wavelengths measured using CCD/spectrometers. We present methods on combining the synergistic attributes of DCE-MR and NIRS for in-vivo imaging of breast cancer in three dimensions using a custom optical MR breast coil and diffusion based light modeling software, NIRFAST. We present results from phantom studies, healthy subjects, and breast cancer patients. Preliminary results show contrast recovery within 10% in phantoms and spatial resolution less than 5mm. Images from healthy subjects were recovered with properties similar to literature values and previous studies. Patient images have shown elevated total hemoglobin values and water fraction, agreeing with histology and previous results. The additional information gained from NIRS may improve the ability to distinguish between malignant and benign lesions during MR imaging. These dual modality instruments will provide complex anatomical and molecular prognostic information, and may decrease the number of biopsies, thereby improving patient care.
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Michael A. Mastanduno, Michael A. Mastanduno, Scott C. Davis, Scott C. Davis, Shudong Jiang, Shudong Jiang, Roberta diFlorio-Alexander, Roberta diFlorio-Alexander, Brian W. Pogue, Brian W. Pogue, Keith D. Paulsen, Keith D. Paulsen, } "Magnetic resonance guided optical spectroscopy imaging of human breast cancer using a combined frequency domain and continuous wave approach", Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83171M (16 April 2012); doi: 10.1117/12.912474; https://doi.org/10.1117/12.912474

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