16 April 2012 Comparison between subjects with long- and short-allele carriers in the BOLD signal within amygdala during emotional tasks
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Abstract
Emotional tasks may result in a strong blood oxygen level-dependent (BOLD) signal in the amygdala in 5- HTTLRP short-allele. Reduced anterior cingulate cortex (ACC)-amygdala connectivity in short-allele provides a potential mechanistic account for the observed increase in amygdala activity. In our study, fearful and threatening facial expressions were presented to two groups of 12 subjects with long- and short-allele carriers. The BOLD signals of the left amygdala of each group were averaged to increase the signal-to-noise ratio. A Bayesian approach was used to estimate the model parameters to elucidate the underlying hemodynamic mechanism. Our results showed a positive BOLD signal in the left amygdala for short-allele individuals, and a negative BOLD signal in the same region for long-allele individuals. This is due to the fact that short-allele is associated with lower availability of serotonin transporter (5-HTT) and this leads to an increase of serotonin (5-HT) concentration in the cACC-amygdala synapse.
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Shamil Hadi, Shamil Hadi, Mohamad R. Siadat, Mohamad R. Siadat, Abbas Babajani-Feremi, Abbas Babajani-Feremi, } "Comparison between subjects with long- and short-allele carriers in the BOLD signal within amygdala during emotional tasks", Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83171Q (16 April 2012); doi: 10.1117/12.905189; https://doi.org/10.1117/12.905189
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