You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither SPIE nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the SPIE website.
16 April 2012Computational study of anterior communicating artery hemodynamics before aneurysm formation
It is widely accepted that complexity in the flow pattern at the anterior communicating artery (AComA) is associated
with the high rate of aneurysm formation in that location observed in large studies. A previous computational
hemodynamic study showed a possible association between high maximum intraaneurysmal wall shear stress (WSS) at
the systolic peak with rupture in a cohort of AComA aneurysms. In another study it was observed a connection between
location of aneurysm blebs and regions of high WSS in models where blebs were virtually removed. However, others
reported associations between low WSS and either rupture or blister formation. The purpose of this work is to study
associations between hemodynamic patterns and AComA aneurysm initiation by comparing hemodynamics in the
aneurysm and the normal model where the aneurysm was computationally removed. Vascular models of both right and
left circulation were independently reconstructed from three-dimensional rotational angiography images using
deformable models, and fused using a surface merging algorithm. The geometric models were then used to generate
high-quality volumetric finite element grids of tetrahedra with an advancing front technique. For each patient, the second
anatomical model was created by digitally removing the aneurysm. It was iteratively achieved by applying a Laplacian
smoothing filter and remeshing the surface. Finite element blood flow numerical simulations were performed. It was
observed that aneurysms initiated in regions of high and moderate WSS in the counterpart normal models. Adjacent or
close to those regions, low WSS portions of the arterial wall were not affected by the disease.
The alert did not successfully save. Please try again later.
Marcelo A. Castro, Christopher M. Putman, Juan R. Cebral, "Computational study of anterior communicating artery hemodynamics before aneurysm formation," Proc. SPIE 8317, Medical Imaging 2012: Biomedical Applications in Molecular, Structural, and Functional Imaging, 83171U (16 April 2012); https://doi.org/10.1117/12.910653