22 February 2012 Inverse dependence of search and classification performances in lesion localization tasks
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Search involves detecting the locations of potential lesions. Classification involves determining if a detected region is a true lesion. The most commonly used measure of observer performance, namely the area A under the ROC curve, is affected by both search and classification performances. The aim was to demonstrate a method for separating these contributions and apply it to several clinical datasets. Search performance S was defined as the square root of 2 times the perpendicular distance of the end-point of the search-model predicted ROC from the chance diagonal. Classification performance C was defined as the separation of the unit-variance binormal distributions for signal and noise sites. Eleven (11) datasets were fitted by the search model and search, classification and trapezoidal A were computed for each modality and reader combination. Kendall-tau correlations were calculated between the resulting S, C and A pairs. Kendall correlation (S vs. C) was smaller than zero for all datasets, and the average Kendall correlation was significantly smaller than 0 (average = -0.401, P = 8.3 x 10-6). Also, Kendall correlation (A vs. S) was larger than zero for 9 out of 11 datasets and the average Kendall correlation was significantly larger than 0 (average = 0.295, P = 2.9 x 10-3). On the other hand average Kendall correlation (A vs. C) was not significantly different from zero (average = 0.102, P = 0.25). The results suggest that radiologists may learn to compensate for poor search performance with better classification performance. This study also indicates that efforts at improving net performance, which currently focus almost exclusively on improving classification performance, may be more successful if aimed at improving search performance.
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D. P. Chakraborty, D. P. Chakraborty, Hong-Jun Yoon, Hong-Jun Yoon, Claudia Mello-Thoms, Claudia Mello-Thoms, } "Inverse dependence of search and classification performances in lesion localization tasks", Proc. SPIE 8318, Medical Imaging 2012: Image Perception, Observer Performance, and Technology Assessment, 83180H (22 February 2012); doi: 10.1117/12.911820; https://doi.org/10.1117/12.911820

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