16 February 2012 A computer-aided detection (CAD) system with a 3D algorithm for small acute intracranial hemorrhage
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Acute Intracranial hemorrhage (AIH) requires urgent diagnosis in the emergency setting to mitigate eventual sequelae. However, experienced radiologists may not always be available to make a timely diagnosis. This is especially true for small AIH, defined as lesion smaller than 10 mm in size. A computer-aided detection (CAD) system for the detection of small AIH would facilitate timely diagnosis. A previously developed 2D algorithm shows high false positive rates in the evaluation based on LAC/USC cases, due to the limitation of setting up correct coordinate system for the knowledge-based classification system. To achieve a higher sensitivity and specificity, a new 3D algorithm is developed. The algorithm utilizes a top-hat transformation and dynamic threshold map to detect small AIH lesions. Several key structures of brain are detected and are used to set up a 3D anatomical coordinate system. A rule-based classification of the lesion detected is applied based on the anatomical coordinate system. For convenient evaluation in clinical environment, the CAD module is integrated with a stand-alone system. The CAD is evaluated by small AIH cases and matched normal collected in LAC/USC. The result of 3D CAD and the previous 2D CAD has been compared.
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Ximing Wang, Ximing Wang, James Fernandez, James Fernandez, Ruchi Deshpande, Ruchi Deshpande, Joon K. Lee, Joon K. Lee, Tao Chan, Tao Chan, Brent Liu, Brent Liu, } "A computer-aided detection (CAD) system with a 3D algorithm for small acute intracranial hemorrhage", Proc. SPIE 8319, Medical Imaging 2012: Advanced PACS-based Imaging Informatics and Therapeutic Applications, 831913 (16 February 2012); doi: 10.1117/12.910958; https://doi.org/10.1117/12.910958

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