Dynamic shape modeling of the mitral valve from real-time 3D ultrasound images using continuous medial representation

Alison M. Pouch; Paul A. Yushkevich; Benjamin M. Jackson; Joseph H. Gorman III; Robert C. Gorman; Chandra M. Sehgal

doi:10.1117/12.910708

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24 February 2012 Dynamic shape modeling of the mitral valve from real-time 3D ultrasound images using continuous medial representation

Alison M. Pouch, Paul A. Yushkevich, Benjamin M. Jackson, Joseph H. Gorman III, Robert C. Gorman, Chandra M. Sehgal

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Proceedings Volume 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy; 832009 (2012) https://doi.org/10.1117/12.910708
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

Purpose: Patient-specific shape analysis of the mitral valve from real-time 3D ultrasound (rt-3DUS) has broad application to the assessment and surgical treatment of mitral valve disease. Our goal is to demonstrate that continuous medial representation (cm-rep) is an accurate valve shape representation that can be used for statistical shape modeling over the cardiac cycle from rt-3DUS images. Methods: Transesophageal rt-3DUS data acquired from 15 subjects with a range of mitral valve pathology were analyzed. User-initialized segmentation with level sets and symmetric diffeomorphic normalization delineated the mitral leaflets at each time point in the rt-3DUS data series. A deformable cm-rep was fitted to each segmented image of the mitral leaflets in the time series, producing a 4D parametric representation of valve shape in a single cardiac cycle. Model fitting accuracy was evaluated by the Dice overlap, and shape interpolation and principal component analysis (PCA) of 4D valve shape were performed. Results: Of the 289 3D images analyzed, the average Dice overlap between each fitted cm-rep and its target segmentation was 0.880±0.018 (max=0.912, min=0.819). The results of PCA represented variability in valve morphology and localized leaflet thickness across subjects. Conclusion: Deformable medial modeling accurately captures valve geometry in rt-3DUS images over the entire cardiac cycle and enables statistical shape analysis of the mitral valve.

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Alison M. Pouch, Paul A. Yushkevich, Benjamin M. Jackson, Joseph H. Gorman III, Robert C. Gorman, and Chandra M. Sehgal "Dynamic shape modeling of the mitral valve from real-time 3D ultrasound images using continuous medial representation", Proc. SPIE 8320, Medical Imaging 2012: Ultrasonic Imaging, Tomography, and Therapy, 832009 (24 February 2012); https://doi.org/10.1117/12.910708

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