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13 March 2012 Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy
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Abstract
Absorption spectra in the terahertz region between 6 and 66 cm-1 (0.2 ~ 2.0 THz) were measured for S-(+)-, R-(-) and RS-naproxen pharmaceutical molecules in crystalline form using time-domain terahertz spectroscopic (THz-TDS) technique at room temperature. Different absorption features were observed for the racemic RS-naproxen and its corresponding enantiomers (S-(+)- and R-(-)-naproxen). The observed THz absorption bands are strikingly sensitive to the change of subtle conformational structures despite that the isostructurality exists within such crystal molecules. The results show that the THz-TDS technique can be definitely used for distinguishing between chiral and racemic compounds in pharmaceutical and biological fields.
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Yong Du, Rongjiao Zhao, Guohui Hao, Changsheng Guo, and Zhi Hong "Conformational characteristics of chiral and racemic naproxen molecules investigated by terahertz time-domain spectroscopy", Proc. SPIE 8330, Photonics and Optoelectronics Meetings (POEM) 2011: Laser and Terahertz Science and Technology, 83300X (13 March 2012); https://doi.org/10.1117/12.918840
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