28 February 2012 Application of optical coherence tomography for assessment of transcutaneous vaccine delivery
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Abstract
Immunization is one of the most efficient and cost-effective means for the prevention of diseases, but most vaccines have to be administered invasively. A novel strategy of inducing an immune response is topical application of vaccines to intact skin. Apart from being a non-invasive route of drug delivery, skin delivery also offers an advantageous mode of immunization due to the ability of skin immune cells to present antigens to the immune system. Topical vaccine penetration through the outermost layers of skin is based on the percutaneous diffusion of lipid-based nano-particles. In the current study we investigate the applicability of Optical Coherence Tomography for monitoring transcutaneous delivery of a peptide vaccine into the skin in vivo.
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T. Kamali, T. Rattanapak, S. Hook, I. Meglinski, "Application of optical coherence tomography for assessment of transcutaneous vaccine delivery", Proc. SPIE 8337, Saratov Fall Meeting 2011: Optical Technologies in Biophysics and Medicine XIII, 833706 (28 February 2012); doi: 10.1117/12.923733; https://doi.org/10.1117/12.923733
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