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28 February 2012 Thermal distribution in biological tissue at laser induced fluorescence and photodynamic therapy
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Abstract
Laser induced fluorescence spectroscopy and photodynamic therapy (PDT) are techniques currently introduced in clinical applications for visualization and local destruction of malignant tumours as well as premalignant lesions. During the laser irradiation of tissues for the diagnostic and therapeutic purposes, the absorbed optical energy generates heat, although the power density of the treatment light for surface illumination is normally low enough not to cause any significantly increased tissue temperature. In this work we tried to evaluate the utility of Monte Carlo modeling for simulating the temperature fields and the dynamics of heat conduction into the skin tissue under several laser irradiation conditions with both a pulsed UV laser and a continuous wave visible laser beam. The analysis of the results showed that heat is not localized on the surface, but it is collected inside the tissue. By varying the boundary conditions on the surface and the type of the laser radiation (continuous or pulsed) we can reach higher than normal temperature inside the tissue without simultaneous formation of thermally damaged tissue (e.g. coagulation or necrosis zone).
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I. V. Krasnikov, A. Yu. Seteikin, E. Drakaki, and M. Makropoulou "Thermal distribution in biological tissue at laser induced fluorescence and photodynamic therapy", Proc. SPIE 8337, Saratov Fall Meeting 2011: Optical Technologies in Biophysics and Medicine XIII, 83370E (28 February 2012); https://doi.org/10.1117/12.923741
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