4 April 2012 Micro- and nanostructured polymer substrates for biomedical applications
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Polymer implants are interesting alternatives to the contemporary load-bearing implants made from metals. Polyetheretherketone (PEEK), a well-established biomaterial for example, is not only iso-elastic to bone but also permits investigating the surrounding soft tissues using magnetic resonance imaging or computed tomography, which is particularly important for cancer patients. The commercially available PEEK bone implants, however, require costly coatings, which restricts their usage. As an alternative to coatings, plasma activation can be applied. The present paper shows the plasma-induced preparation of nanostructures on polymer films and on injection-molded micro-cantilever arrays and the associated chemical modifications of the surface. In vitro cell experiments indicate the suitability of the activation process. In addition, we show that microstructures such as micro-grooves 1 μm deep and 20 μm wide cause cell alignment. The combination of micro-injection molding, simultaneous microstructuring using inserts/bioreplica and plasma treatments permits the preparation of polymer implants with nature-analogue, anisotropic micro- and nanostructures.
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Jasmin Althaus, Prabitha Urwyler, Celestino Padeste, Roman Heuberger, Hans Deyhle, Helmut Schift, Jens Gobrecht, Uwe Pieles, Dieter Scharnweber, Kirsten Peters, Bert Müller, "Micro- and nanostructured polymer substrates for biomedical applications", Proc. SPIE 8339, Bioinspiration, Biomimetics, and Bioreplication 2012, 83390Q (4 April 2012); doi: 10.1117/12.915235; https://doi.org/10.1117/12.915235

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