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Neural recording through microelectrodes requires biocompatibility and long term chronic usage. With a
potential for various applications and effort to improve the performance of neural recording probes, consideration is
taken to the tissue and cellular effects in these device designs. The degeneration of neurons due to brain tissue motion is
an issue along with brain tissue inflammation in the insertion of the probes. To account for motion and irritation the
material structure of the probes must be improved upon. This research presents the fabrication of neural probes on the
microscale utilizing flexible polymers. Polyimide neural probes have been considered possibly to reduce degradation in
their variability caused by brain motion. The microfabrication of the polyimide neural probe has an increased flexibility
while accounting for biocompatibility and the needs for chronic use. Through microfabrication processes a needle probe
is produced and tested for neural recording.
Courtney Smith,Kyo D. Song,Hargsoon Yoon,Woong-Ki Kim,Tao Zeng, andLarry D. Sanford
"Development and investigation of flexible polymer neural probe
for chronic neural recording", Proc. SPIE 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012, 834404 (30 March 2012); https://doi.org/10.1117/12.917481
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Courtney Smith, Kyo D. Song, Hargsoon Yoon, Woong-Ki Kim, Tao Zeng, Larry D. Sanford, "Development and investigation of flexible polymer neural probe for chronic neural recording," Proc. SPIE 8344, Nanosensors, Biosensors, and Info-Tech Sensors and Systems 2012, 834404 (30 March 2012); https://doi.org/10.1117/12.917481