20 April 2012 Fabrication and characterization of polymer gel for MRI phantom with embedded lesion particles
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Abstract
Magnetic Resonance Imaging (MRI) is a medical imaging technique used in radiology to visualize the detailed internal structure and body soft tissues in complete 3D image. MRI performs best when optimal imaging parameters such as contrast, signal to noise ratio (SNR), spatial resolution and total scan time are utilized. However, due to a variety of imaging parameters that differ with the manufacturer, a calibration medium that allows the control of these parameters is necessary. Therefore, a phantom that behaves similar to human soft tissue is developed to replace a real human. Polymer gel is novel material that has great potential in the medical imaging. Since very few have focused on examining the behavior of polymer lesions, the motivation of this study is to develop a polymer gel phantom, especially for liver, with embedded lesions. Both the phantom and lesions should be capable of reflecting T1 and T2 relaxation values through various characterization processes. In this paper, phantom and lesion particles were fabricated with carrageenan as a gelling agent by physical aggregation. Agar was used as supplementary gelling agent and T2 modifier and Gd-DTPA as T1 modifier. The polymer gel samples were fabricated by varying the concentrations of the gelling agent, and T1 and T2 modifiers. The lesion particles were obtained by extracting molten polymer gel solution in chilled oil bath to obtain spherical shape. The polymer gel properties including density, elastic modulus, dielectric constant and optical properties were measured to compare with human tissue values for long period of time.
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Eunji In, Eunji In, Hani E. Naguib, Hani E. Naguib, Masoom Haider, Masoom Haider, } "Fabrication and characterization of polymer gel for MRI phantom with embedded lesion particles", Proc. SPIE 8348, Health Monitoring of Structural and Biological Systems 2012, 83480V (20 April 2012); doi: 10.1117/12.915034; https://doi.org/10.1117/12.915034
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