4 May 2012 Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates
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Abstract
The prevalence of multidrug-resistant infections in personnel wounded in Iraq and Afghanistan has made it challenging for physicians to choose effective therapeutics in a timely fashion. To address the challenge of identifying the potential for drug resistance, we have developed the Antimicrobial Resistance Determinant Microarray (ARDM) to provide DNAbased analysis for over 250 resistance genes covering 12 classes of antibiotics. Over 70 drug-resistant bacteria from different geographic regions have been analyzed on ARDM, with significant differences in patterns of resistance identified: genes for resistance to sulfonamides, trimethoprim, chloramphenicol, rifampin, and macrolide-lincosamidesulfonamide drugs were more frequently identified in isolates from sources in Iraq/Afghanistan. Of particular concern was the presence of genes responsible for resistance to many of the last-resort antibiotics used to treat war traumaassociated infections.
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Chris Rowe Taitt, Chris Rowe Taitt, Tomasz Leski, Tomasz Leski, David Stenger, David Stenger, Gary J. Vora, Gary J. Vora, Brent House, Brent House, Matilda Nicklasson, Matilda Nicklasson, Guillermo Pimentel, Guillermo Pimentel, Daniel V. Zurawski, Daniel V. Zurawski, Benjamin C. Kirkup, Benjamin C. Kirkup, David Craft, David Craft, Paige E. Waterman, Paige E. Waterman, Emil P. Lesho, Emil P. Lesho, Umaru Bangurae, Umaru Bangurae, Rashid Ansumana, Rashid Ansumana, } "Antimicrobial resistance determinant microarray for analysis of multi-drug resistant isolates", Proc. SPIE 8371, Sensing Technologies for Global Health, Military Medicine, Disaster Response, and Environmental Monitoring II; and Biometric Technology for Human Identification IX, 83710X (4 May 2012); doi: 10.1117/12.924569; https://doi.org/10.1117/12.924569
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