7 May 2012 Molecular targeting in childhood malignancies using nanoparticles
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Abstract
The goal of our project is to develop a new therapy for childhood malignancies using nanoformulated siRNA targeting Mxd3, a molecule in the Sonic Hedgehog signaling pathway, which we believe is important for cell survival. We plan to use cancer-specific ligands and superparamagnetic iron oxide nanoparticles (SPIO NPs) to carry siRNA. This delivery system will be tested in mouse xenograft models that we developed with primary cancer tissues. Our current focus is acute lymphoblastic leukemia (ALL), the most common cancer in children. We report our progress to date.
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Noriko Satake, Gustavo Barisone, Elva Diaz, Nitin Nitin, Jan Nolta, Kit Lam, "Molecular targeting in childhood malignancies using nanoparticles", Proc. SPIE 8373, Micro- and Nanotechnology Sensors, Systems, and Applications IV, 83730N (7 May 2012); doi: 10.1117/12.920917; https://doi.org/10.1117/12.920917
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