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19 May 2012 Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection in aqueous solution
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Abstract
We describe and demonstrate a physical mechanism that substantially enhances the label-free sensitivity of a Whispering-Gallery-Mode biosensor for the detection of individual nanoparticles in aqueous solution. It involves the interaction of dielectric nanoparticle in an equatorial carousel orbit with a plasmonic nanoparticle bound on the orbital path. As a 60 nm dielectric particle parks on plasmonic hot spots we observe frequency shifts that are considerably enhanced consistent with a simple reactive model. Using the same model the label free detection of a single bovine serum albumin (BSA) molecule is projected.
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S. I. Shopova, R. Rajmangal, S. Holler, and S. Arnold "Plasmonic enhancement of a whispering-gallery-mode biosensor for single nanoparticle detection in aqueous solution", Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 837605 (19 May 2012); https://doi.org/10.1117/12.920614
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