19 May 2012 In vivo experiments of laser thermotherapy on liver tissue with FBG temperature distribution sensor
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Abstract
In this paper, we report an in vivo experimental study of liver tissue during Laser Induced Interstitial Thermotherapy (LITT). Single FBG was used in the experiments to measure the temperature distribution profile of the bio tissue in real time. Ideally, the goal of LITT is to kill pathological tissue thoroughly and minimize its damage to surrounding healthy tissue, especially vital organs. The extent of treated tissue damage in the therapy is mainly dependent on the irradiation time and the laser power density at the tissue surface. Therefore, monitoring the dynamic change of the exact temperature distribution of the tissue is a key point for the safety of this treatment. In our experiments, FBG was embedded in the laser irradiated bio tissues and used as fully distributed temperature sensor. During the therapy, its reflection spectra were recorded and transmitted to PC in real time. The temperature profile along the FBG axial was reconstructed from its reflection spectrum by the spectra inversion program running on the PC. We studied the dependence of the temperature distribution and the laser output power experimentally and compared the results of in vivo and in vitro under similar laser irradiating conditions. Experimental results demonstrate the effectiveness of this method. Due to influence of body temperature, the in vivo measured temperature is higher than the in vitro one with an almost constant temperature difference value, but the slope and trend of the measured temperature curves in vivo and in vitro are almost identical.
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Na Chen, Shaofeng Chen, Hongfei Zhu, Shupeng Liu, Zhenyi Chen, Fufei Pang, Tingyun Wang, "In vivo experiments of laser thermotherapy on liver tissue with FBG temperature distribution sensor", Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 83760B (19 May 2012); doi: 10.1117/12.919168; https://doi.org/10.1117/12.919168
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