19 May 2012 Highly sensitive detection of glucose concentration with opto-fluidics ring resonator
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Abstract
Noninvasive detection of glucose has been heavily researched in their roles of offering cost-effective, painless, and bloodless monitoring of glucose concentration. In this work, we describe a novel, label-free, and sensitive approach for detecting the glucose concentration in human interstitial fluid samples using the opto-fluidic ring resonator (OFRR). The OFRR incorporates microfluidics and optical ring resonator sensing technology to achieve rapid label-free detection in a small and low-cost platform. In this study, bulk refractive index measurements are presented. Results show that the OFRR is able to detect glucose at medically relevant concentrations in interstitial fluid ranging from 0 to 25 mM, with a detection limit of 0.32 mM, which is lower than clinical requirement by one order of magnitude. Our work is believed to lead to a device that can be used to frequently monitor glucose concentration in a low-cost and painless manner.
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Yunhan Luo, Yunhan Luo, Maung Kyaw Khaing Oo, Maung Kyaw Khaing Oo, Jia Ge, Jia Ge, Zhe Chen, Zhe Chen, Xudong Fan, Xudong Fan, } "Highly sensitive detection of glucose concentration with opto-fluidics ring resonator", Proc. SPIE 8376, Photonic Microdevices/Microstructures for Sensing IV, 83760C (19 May 2012); doi: 10.1117/12.921102; https://doi.org/10.1117/12.921102
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