Ultrasound guided fluorescence tomography

Baoqiang Li; Frederic Lesage

doi:10.1117/12.2001441

Abstract

In this study, a hybrid-model imaging system combining fluorescence and ultrasound (US) was investigated with the motivation of providing structural priors towards improvement of fluorescence reconstruction. A single element transducer was scanned over the sample for anatomy. In the fluorescence part, a laser source was scanned over the sample with the emission received by an EMCCD camera. Synchronization was achieved by a pair of motorized linear stages. Structural information was derived from the US images and a profilometry and used to constrain reconstruction. In the reconstruction, we employed a GPU-based Monte Carlo simulation for forward modeling and a pattern-based method to take advantage of the huge dataset for the inverse problem. Performance of this system was validated with two phantoms with fluorophore inclusions. The results indicated that the fluorophore distribution could be accurately reconstructed. And the system has a potential for the future in-vivo study.

Citation Download Citation

Baoqiang Li, Baoqiang Li, Frederic Lesage, Frederic Lesage, "Ultrasound guided fluorescence tomography", Proc. SPIE 8412, Photonics North 2012, 841208 (24 October 2012); doi: 10.1117/12.2001441; https://doi.org/10.1117/12.2001441

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