A novel assay for rapid HIV-1 protease detection using optical sensors and magnetic carriers

Chiheb Esseghaier; Andy Ng; Mohammed Zourob

doi:10.1117/12.2001479

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24 October 2012 A novel assay for rapid HIV-1 protease detection using optical sensors and magnetic carriers

Chiheb Esseghaier, Andy Ng, Mohammed Zourob

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Proceedings Volume 8412, Photonics North 2012; 841209 (2012) https://doi.org/10.1117/12.2001479
Event: Photonics North 2012, 2012, Montréal, Canada

Abstract

In this work, a very simple electrochemical HIV-1 protease biosensor useful for the development of an inexpensive lab-on-a- chip (LOC) device was constructed. The detection mechanism was designed to minimize the complexity either in the recognition receptor immobilization step or during the detection itself. The magnetic self-assembled monolayer of HIV-1 protease substrate peptide was able to detect as low as 10 pg/ml of the protease within 25 minutes with high specificity.

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Chiheb Esseghaier, Andy Ng, and Mohammed Zourob "A novel assay for rapid HIV-1 protease detection using optical sensors and magnetic carriers", Proc. SPIE 8412, Photonics North 2012, 841209 (24 October 2012); https://doi.org/10.1117/12.2001479

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