Biosensing using long-range surface plasmon-polariton waveguides is demonstrated. Current sensor consists of gold straight waveguides (SWGs) embedded in CYTOP with etched microfluidic channels. The sensing platform is capable of detecting analytes with a small mass as well as monitoring the change in refractive index of bulk solutions. Three solutions with different refractive indices were tested for bulk sensitivity: a mixture of Phosphate Buffered Saline (PBS) and Glycerol (7.25% w/w), Distilled/Deionized water and 2-Isopropanol. Protein Bovine Serum Albumin (BSA) was physisorbed on carboxyl-terminated self-assembled monolayer (SAM). A significant change in signal has been observed for these experiments.