17 October 2012 Suspended core optical fibers for biological applications using UV wavelengths
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Proceedings Volume 8421, OFS2012 22nd International Conference on Optical Fiber Sensors; 84211E (2012) https://doi.org/10.1117/12.970611
Event: OFS2012 22nd International Conference on Optical Fiber Sensor, 2012, Beijing, China
Abstract
We have demonstrated the use of suspended core optical fibers as dip sensors for biological applications based on fluorophores operating at UV wavelengths for the first time. In this paper, we have demonstrated the use of suspended-core fibers to measure the fluorescence of 7-Amino-4-methylcoumarin (AMC), which is used as the transduction for the standard enzyme activity assay of PC6, a biomarker of women's uterine fertility. Concentrations down to 500 nM have been measured using a 2.1 μm core diameter fiber.
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S. C. Warren-Smith, S. C. Warren-Smith, G. Nie, G. Nie, J. Kobelke, J. Kobelke, R. Kostecki, R. Kostecki, L. A. Salamonsen, L. A. Salamonsen, T. M. Monro, T. M. Monro, "Suspended core optical fibers for biological applications using UV wavelengths", Proc. SPIE 8421, OFS2012 22nd International Conference on Optical Fiber Sensors, 84211E (17 October 2012); doi: 10.1117/12.970611; https://doi.org/10.1117/12.970611
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