30 April 2012 Graphene-based high-performance surface plasmon resonance biosensors
Author Affiliations +
Abstract
Surface plasmon resonance (SPR) biosensors have become a central tool for the study of biomolecular interactions, chemical detection, and immunoassays in various fields. SPR biosensors offer unparalleled advantages such as label-free and real-time analysis with very high sensitivity. To further push the limits of SPR capabilities, novel SPR structures and approaches are being actively investigated. Here we experimentally demonstrate a graphene-based SPR biosensor. By incorporating a graphene layer to the conventional gold thin film SPR structure, its biosensing sensitivity is significantly increased. This is shown in a typical affinity biosensing experiment to measure the real-time binding kinetics of biotin-streptavidin. In addition to higher sensitivity, we also obtain a much higher signal-to-noise ratio without the slightest modification of the usual measurement setup. This implies that a considerably lower limit of detection can be made possible with the novel structure. Moreover, our graphene-based SPR biosensors do not require sophisticated surface functionalization schemes as in conventional SPR in order to function. Previous reports have also suggested that graphene might effectively prevent non-specific binding of biomolecules on the sensor surface. With relatively simple fabrication methods and large scalability, these combined distinctive advantages can enable future generation of high-performance SPR biosensors.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
E. Wijaya, E. Wijaya, N. Maalouli, N. Maalouli, R. Boukherroub, R. Boukherroub, S. Szunerits, S. Szunerits, J.-P. Vilcot, J.-P. Vilcot, } "Graphene-based high-performance surface plasmon resonance biosensors", Proc. SPIE 8424, Nanophotonics IV, 84240R (30 April 2012); doi: 10.1117/12.921670; https://doi.org/10.1117/12.921670
PROCEEDINGS
7 PAGES


SHARE
Back to Top