1 May 2012 Fabrication of ZnO nanostructures and their application in biomedicine
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In this study, we synthesized different types of ZnO samples (thin and nanostructured films) and investigated their potential application in biomedicine. The properties of ZnO films are strongly dependent on the synthesis process and the experimental conditions. Thus, the samples were prepared by pulsed laser deposition (PLD), which allows excellent control over the stoichiometry and surface morphology. Cell suspensions of the same concentration and volume (i.e. same number of cells) were seeded on each sample. The subjects of interest were 3T3 fibroblast, MCF-7 and HeLa cancer cells. The influence of the ZnO surface morphology on the viability of these three different cell cultures was studied. The cell type defines the appropriate surface morphology for cell culturing. The nanoscale morphology of the samples supports the HeLa cell viability, while only a small quantity of MCF-7 cells are able to adhere, spread and survive on them.
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A. Og. Dikovska, N. Ts. Tsankov, R. Toshkova, E. Gardeva, L. Yossifova, N. N. Nedyalkov, P. A. Atanasov, "Fabrication of ZnO nanostructures and their application in biomedicine", Proc. SPIE 8424, Nanophotonics IV, 84242Q (1 May 2012); doi: 10.1117/12.922406; https://doi.org/10.1117/12.922406

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