8 May 2012 Fluorescence-enhanced optical spectroscopy using early arriving photons in transmission mode: a finite element approach
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Optical imaging of turbid media is a challenging problem mainly due to the scattering process that reduces image contrast and degrades spatial resolution. The development of fluorescent probes has recently improved the noninvasive optical technique. In this paper, we are interested in the time gating fluorescence signals. The diffusion approximation is used in order to describe the light propagation of a laser pulse in a turbid media that mimics breast like biological tissue. A numerical model based on a finite element method is proposed. Fluorescence time dependent numerical simulations are performed in order to compute time-gated intensities resulting from line scans across partially absorbing and scattering slab configurations. Optical properties of embedded objects are chosen to be the same as optical properties of breast tumor. Tacking into account two hidden objects, we investigate the lateral resolution aimed by fluorescence modality, and we also compared the results to thus obtained by photon propagation. Different widths of the time gate are computed and it is demonstrated that both lateral localization of one inclusion, and resolution of two inclusions, are enhanced when the time-gate width (▵t) is decreased. The overall computations confirm that fluorescent time-gating technique is very sensitive to local variations in optical properties that are due to breast-like tumors in turbid media.
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Vianney Piron, Vianney Piron, Jean-Pierre L'Huillier, Jean-Pierre L'Huillier, } "Fluorescence-enhanced optical spectroscopy using early arriving photons in transmission mode: a finite element approach", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 84271P (8 May 2012); doi: 10.1117/12.922516; https://doi.org/10.1117/12.922516

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