8 May 2012 Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer
Author Affiliations +
Abstract
Photodynamic therapy (PDT) is an emerging technique for the treatment of cancerous and non-cancerous conditions. Gold nanoparticles (GNPs) possess unique physical and chemical properties which allow them to act as multifunctional agents in nanomedicine. GNP- photosensitizer conjugates have attracted increasing attention in drug delivery for photodynamic cancer therapy. In the present investigation, we prepared covalent conjugates of the photosensitizer Toluidine Blue O (TBO) and thiol protected GNPs. The suitability of TBO- GNPs conjugates for in vitro PDT was assayed using the SW480 Human colon adenocarcinoma cell line. Our results suggest that gold nanoparticle conjugates are an excellent vehicle for delivery of photosensitizer agents in the photodynamic therapy of cultured tumour cells.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Rasoul Al-Majmaie, Nebras Alattar, Dominic Zerulla, Mohamed Al-Rubeai, "Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842722 (8 May 2012); doi: 10.1117/12.921813; https://doi.org/10.1117/12.921813
PROCEEDINGS
6 PAGES


SHARE
Back to Top