8 May 2012 Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer
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Proceedings Volume 8427, Biophotonics: Photonic Solutions for Better Health Care III; 842722 (2012); doi: 10.1117/12.921813
Event: SPIE Photonics Europe, 2012, Brussels, Belgium
Abstract
Photodynamic therapy (PDT) is an emerging technique for the treatment of cancerous and non-cancerous conditions. Gold nanoparticles (GNPs) possess unique physical and chemical properties which allow them to act as multifunctional agents in nanomedicine. GNP- photosensitizer conjugates have attracted increasing attention in drug delivery for photodynamic cancer therapy. In the present investigation, we prepared covalent conjugates of the photosensitizer Toluidine Blue O (TBO) and thiol protected GNPs. The suitability of TBO- GNPs conjugates for in vitro PDT was assayed using the SW480 Human colon adenocarcinoma cell line. Our results suggest that gold nanoparticle conjugates are an excellent vehicle for delivery of photosensitizer agents in the photodynamic therapy of cultured tumour cells.
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Rasoul Al-Majmaie, Nebras Alattar, Dominic Zerulla, Mohamed Al-Rubeai, "Toluidine blue O-conjugated gold nanoparticles for photodynamic therapy of cultured colon cancer", Proc. SPIE 8427, Biophotonics: Photonic Solutions for Better Health Care III, 842722 (8 May 2012); doi: 10.1117/12.921813; https://doi.org/10.1117/12.921813
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KEYWORDS
Photodynamic therapy

Nanoparticles

Gold

In vitro testing

Colon

Colorectal cancer

Helium neon lasers

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