10 October 2012 A viral peptide for intracellular delivery
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Abstract
Biological membranes represent a critical hindrance for administering active molecules which are often unable to reach their designated intracellular target sites. In order to overcome this barrier-like behavior not easily circumvented by many pharmacologically-active molecules, synthetic transporters have been exploited to promote cellular uptake. Linking or complexing therapeutic molecules to peptides that can translocate through the cellular membranes could enhance their internal delivery, and consequently, a higher amount of active compound would reach the site of action. Use of cell penetrating peptides (CPPs) is one of the most promising strategy to efficiently translocate macromolecules through the plasma membrane, and have attracted a lot of attention. New translocating peptides are continuously described and in the present review, we will focus on viral derived peptides, and in particular a peptide (gH625) derived from the herpes simplex virus type 1 (HSV-1) glycoprotein H (gH) that has proved to be a useful delivery vehicle due to its intrinsic properties of inducing membrane perturbation.
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Annarita Falanga, Annarita Falanga, Rossella Tarallo, Rossella Tarallo, Marco Cantisani, Marco Cantisani, Maria Elena Della Pepa, Maria Elena Della Pepa, Massimiliano Galdiero, Massimiliano Galdiero, Stefania Galdiero, Stefania Galdiero, } "A viral peptide for intracellular delivery", Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600K (10 October 2012); doi: 10.1117/12.970471; https://doi.org/10.1117/12.970471
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