Paper
10 October 2012 Porous silicon photonic crystals for detection of infections
B. Gupta, B. Guan, P. J. Reece, J. J. Gooding
Author Affiliations +
Abstract
In this paper we demonstrate the possibility of modifying porous silicon (PSi) particles with surface chemistry and immobilizing a biopolymer, gelatin for the detection of protease enzymes in solution. A rugate filter, a one-dimensional photonic crystal, is fabricated that exhibits a high-reflectivity optical resonance that is sensitive to small changes in the refractive index. To immobilize gelatin in the pores of the particles, the hydrogen-terminated silicon surface was first modified with an alkyne, 1,8-nonadiyne via hydrosilylation to protect the silicon surfaces from oxidation. This modification allows for further functionality to be added such as the coupling of gelatin. Exposure of the gelatin modified particles to the protease subtilisin in solution causes a change in the refractive index, resulting in a shift of the resonance to shorter wavelengths, indicating cleavage of organic material within the pores. The ability to monitor the spectroscopic properties of microparticles, and shifts in the optical signature due to changes in the refractive index of the material within the pore space, is demonstrated.
© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
B. Gupta, B. Guan, P. J. Reece, and J. J. Gooding "Porous silicon photonic crystals for detection of infections", Proc. SPIE 8460, Biosensing and Nanomedicine V, 84600Z (10 October 2012); https://doi.org/10.1117/12.940757
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KEYWORDS
Silicon

Particles

Photonic crystals

Reflectivity

Refractive index

Optical coatings

Crystals

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