24 October 2012 Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy
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Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 85482E (2012) https://doi.org/10.1117/12.2001967
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of
Abstract
The ultrasensitive and selective diagnosis along with efficient therapy in earliest stage of cancer has been enormously highlighted by a better means to treat the cancer. Herein, Gd (III) chelated polyaniline nanoparticles (GPNPs) was synthesized to be served as a highly T1 enhanced contrast agents and Near-Infrared photothermal therapy probes. In addition, therapeutic antibody was conjugated on the surface of GPNPs for the targeted theragnosis. Fabricated GPNPs significantly reduced the T1 of water protons with as well as represented photothermal ability. The physicochemical properties and biocompatibilities of GNPSs were fully characterized and GPNPs exhibited excellent tumor targeting ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and photothermal ablation of epithelial cancer cells.
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Taeksu Lee, Taeksu Lee, Doyeon Bang, Doyeon Bang, Jin-Suck Suh, Jin-Suck Suh, Yong-Min Huh, Yong-Min Huh, Seungjoo Haam, Seungjoo Haam, } "Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 85482E (24 October 2012); doi: 10.1117/12.2001967; https://doi.org/10.1117/12.2001967
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