24 October 2012 Properties of herbal extracts against Propionibacterium acnes for biomedical application
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Proceedings Volume 8548, Nanosystems in Engineering and Medicine; 854849 (2012) https://doi.org/10.1117/12.2000074
Event: SPIE Nanosystems in Engineering + Medicine, 2012, Incheon, Korea, Republic of
Abstract
Propionibacterium acnes (P. acnes), one of the anaerobic bacterium, causes inflammatory acne. To find a novel medication for treating the inflammation caused by P. acnes, we investigated the anti-bacterial and anti-inflammatory activities of several herbal extracts against P. acnes. The aqueous extracts from five dried herbs, Phellodendron amurense Rupr., Paeonia lactiflora Pallas., Houttuynia cordata Thunb., Agrimonia pilosa Ledeb. and Glycyrrhiza uralensis Fisch., were prepared and mixed. In this experiment, 1 mg/ml of the herbal extract mixture caused a decrease in the growth of P. acnes and reduced the production of pro-inflammatory cytokines, TNF-α, IL-8, IL-1β and IL-6, in human monocytic THP-1 cells treated with heat-killed P. acnes. Therefore, this herbal extract mixture may possess both anti-bacterial and anti-inflammatory activities against P. acnes and can be a novel therapeutic agent for treating inflammatory acne.
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Youn-Mook Lim, Youn-Mook Lim, Sung Eun Kim, Sung Eun Kim, Yong Soo Kim, Yong Soo Kim, Young Min Shin, Young Min Shin, Sung In Jeong, Sung In Jeong, Sun-Young Jo, Sun-Young Jo, Hui-Jeong Gwon, Hui-Jeong Gwon, Jong-seok Park, Jong-seok Park, Young-Chang Nho, Young-Chang Nho, Jong-Cheol Kim, Jong-Cheol Kim, Seong-Jang Kim, Seong-Jang Kim, HeungSoo Shin, HeungSoo Shin, } "Properties of herbal extracts against Propionibacterium acnes for biomedical application", Proc. SPIE 8548, Nanosystems in Engineering and Medicine, 854849 (24 October 2012); doi: 10.1117/12.2000074; https://doi.org/10.1117/12.2000074
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