11 December 2012 Coherent fiber supercontinuum laser for nonlinear biomedical imaging
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Abstract
Nonlinear biomedical imaging has not benefited from the well-known techniques of fiber supercontinuum generation for reasons such as poor coherence (or high noise), insufficient controllability, low spectral power intensity, and inadequate portability. Fortunately, a few techniques involving nonlinear fiber optics and femtosecond fiber laser development have emerged to overcome these critical limitations. These techniques pave the way for conducting point-of-care nonlinear biomedical imaging by a low-maintenance cost-effective coherent fiber supercontinuum laser, which covers a broad emission wavelength of 350-1700 nm. A prototype of this laser has been demonstrated in label-free multimodal nonlinear imaging of cell and tissue samples.
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Haohua Tu, Yuan Liu, Xiaomin Liu, Jesper Lægsgaard, Dmitry Turchinovich, Stephen A. Boppart, "Coherent fiber supercontinuum laser for nonlinear biomedical imaging", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85530A (11 December 2012); doi: 10.1117/12.999522; https://doi.org/10.1117/12.999522
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