11 December 2012 Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy
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Abstract
Multiphoton microscopy (MPM), a noninvasive optical method with high resolution and high sensitivity, can obtain detailed microstructures of biotissues at submolecular level. In this study, MPM is used to image microstructure varieties of human colonic mucosa and submucosa with adenocarcinoma. Some parameters, such as gland configuration, SHG/TPEF intensity ratio, and collagen orientation and so on, should serve the indicators of early colorectal cancer. The exploratory results show that it's potential for the development of multiphoton mini-endoscopy in real-time early diagnosis of colorectal cancer.
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Nenrong Liu, Nenrong Liu, Rong Chen, Rong Chen, Hongsheng Li, Hongsheng Li, Jianxin Chen, Jianxin Chen, } "Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855318 (11 December 2012); doi: 10.1117/12.999860; https://doi.org/10.1117/12.999860
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