11 December 2012 Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy
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Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 855318 (2012); doi: 10.1117/12.999860
Event: Photonics Asia, 2012, Beijing, China
Abstract
Multiphoton microscopy (MPM), a noninvasive optical method with high resolution and high sensitivity, can obtain detailed microstructures of biotissues at submolecular level. In this study, MPM is used to image microstructure varieties of human colonic mucosa and submucosa with adenocarcinoma. Some parameters, such as gland configuration, SHG/TPEF intensity ratio, and collagen orientation and so on, should serve the indicators of early colorectal cancer. The exploratory results show that it's potential for the development of multiphoton mini-endoscopy in real-time early diagnosis of colorectal cancer.
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Nenrong Liu, Rong Chen, Hongsheng Li, Jianxin Chen, "Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855318 (11 December 2012); doi: 10.1117/12.999860; https://doi.org/10.1117/12.999860
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