11 December 2012 Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy
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Abstract
A novel series of zinc (II) phthalocyanines bearing four poly (aryl benzyl ether) dendritic substituents with carboxylic acid functionalities (Gn-DPcZn (Gn=n-generation dendrimer, n=1-2)) loaded polymeric micelles (Gn-DPcZn/m) were formed. The time-dependent intracellular uptake of Gn-DPcZn in RPE cells increased as they were incorporated into micelles, but inversely correlated with the generation. The photocytoxity of Gn-DPcZn was improved by incorporation into polymeric micelles and increased with the generation.
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Kuizhi Chen, Kuizhi Chen, Ming Yu, Ming Yu, Hong Zhang, Hong Zhang, Dongdong Ma, Dongdong Ma, Shujuan Pang, Shujuan Pang, Wei Huang, Wei Huang, Yiru Peng, Yiru Peng, } "Polyion complex micelles incorporating poly (aryl benzyl ether) dendritic phthalocyanine: effective photosensitizers for enhanced photodynamic therapy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532C (11 December 2012); doi: 10.1117/12.2001194; https://doi.org/10.1117/12.2001194
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