Scattering properties of normal and cancerous tissues from human stomach based on phase-contrast microscope

Hui Zhang; Zhifang Li; Hui Li

doi:10.1117/12.981956

11 December 2012 Scattering properties of normal and cancerous tissues from human stomach based on phase-contrast microscope

Hui Zhang, Zhifang Li, Hui Li

Author Affiliations +

Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85532R (2012) https://doi.org/10.1117/12.981956
Event: Photonics Asia, 2012, Beijing, China

Abstract

In order to study scattering properties of normal and cancerous tissues from human stomach, we collect images for human gastric specimens by using phase-contrast microscope. The images were processed by the way of mathematics morphology. The equivalent particle size distribution of tissues can be obtained. Combining with Mie scattering theory, the scattering properties of tissues can be calculated. Assume scattering of light in biological tissue can be seen as separate scattering events by different particles, total scattering properties can be equivalent to as scattering sum of particles with different diameters. The results suggest that scattering coefficient of the cancerous tissue is significantly higher than that of normal tissue. The scattering phase function is different especially in the backscattering area. Those are significant clinical benefits to diagnosis cancerous tissue

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Hui Zhang, Zhifang Li, and Hui Li "Scattering properties of normal and cancerous tissues from human stomach based on phase-contrast microscope", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532R (11 December 2012); https://doi.org/10.1117/12.981956

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KEYWORDS

Tissues

Scattering

Mie scattering

Light scattering

Particles

Stomach

Cancer

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