In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation variations with photoacoustic microscopy

Zhongjiang Chen; Sihua Yang; Da Xing

doi:10.1117/12.999746

11 December 2012 In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation variations with photoacoustic microscopy

Zhongjiang Chen, Sihua Yang, Da Xing

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Proceedings Volume 8553, Optics in Health Care and Biomedical Optics V; 85532U (2012) https://doi.org/10.1117/12.999746
Event: Photonics Asia, 2012, Beijing, China

Abstract

A method for noninvasive simultaneously detecting hemoglobin oxygen saturation (SO₂) and carboxyhemoglobin saturation (SCO) in subcutaneous microvasculature with multi-wavelength photoacoustic microscopy (PAM) is presented. In vitro blood samples mixed with different concentration of carboxyhemoglobin were used to testify the feasibility and accuracy of the PAM. Moreover, fixed-point detection of SO₂ and SCO of the vessel in mouse ear were obtained. And the changes of SO₂ and SCO from normoxia to carbon monoxia hypoxia were dynamically recorded in vivo. Experimental results demonstrate that the PAM has the capability to detect SO₂ and SCO, which has potential application in clinic.

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Zhongjiang Chen, Sihua Yang, and Da Xing "In vivo detection of hemoglobin oxygen saturation and carboxyhemoglobin saturation variations with photoacoustic microscopy", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532U (11 December 2012); https://doi.org/10.1117/12.999746

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KEYWORDS

Blood

Carbon monoxide

In vivo imaging

Oxygen

Photoacoustic microscopy

Arteries

Veins

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