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11 December 2012 Miniature interferometer for refractive index measurement in microfluidic chip
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The design and development of the miniaturized interferometer for measurement of the refractive index or concentration of sub-microliter volume aqueous solution in microfludic chip is presented. It is manifested by a successful measurement of the refractive index of sugar-water solution, by utilizing a laser diode for light source and the small robust instrumentation for practical implementation. Theoretically, the measurement principle and the feasibility of the system are analyzed. Experimental device is constructed with a diode laser, lens, two optical plate and a complementary metal oxide semiconductor (CMOS). Through measuring the positional changes of the interference fringes, the refractive index change are retrieved. A refractive index change of 10-4 is inferred from the measured image data. The entire system is approximately the size of half and a deck of cards and can operate on battery power for long time.
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Minghui Chen, Martial Geiser, Frederic Truffer, and Chengli Song "Miniature interferometer for refractive index measurement in microfluidic chip", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 85532Z (11 December 2012);


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