11 December 2012 ERK-dependent activation of Sp1 is required for low-power laser irradiation-induced vascular endothelial cell proliferation
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Abstract
Here, we report that low-power laser irradiation (LPLI) activates ERK/Sp1 pathway to upregulate VEGF expression and promote vascular endothelial cell proliferation. We demonstrate for the first time that LPLI enhances DNA-binding activity and transactivation activity of Sp1 on VEGF promoter. Additionally, ERK translocates from cytoplasm to nucleus following LPLI. Moreover, activated ERK phosphorylates Sp1 and results in increased EKR-Sp1 interaction. Selective inhibition of Sp1 or ERK suppresses the effect of LPLI on the promotion of cell cycle progression and proliferation. These findings provide a novel link between LPLI and angiogenesis, supplying potential therapy strategies for angiogenesis with LPLI.
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Jie Feng, Jie Feng, Da Xing, Da Xing, } "ERK-dependent activation of Sp1 is required for low-power laser irradiation-induced vascular endothelial cell proliferation", Proc. SPIE 8553, Optics in Health Care and Biomedical Optics V, 855332 (11 December 2012); doi: 10.1117/12.999836; https://doi.org/10.1117/12.999836
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