8 March 2013 Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: a receptor-targeted contrast agent
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Abstract
Cybesin, a smart contrast agent to target cancer cells, was investigated using a near infrared (NIR) spectral polarization imaging technique for prostate cancer detection. The approach relies on applying a contrast agent that can target cancer cells. Cybesin, as a small ICG-derivative dye-peptide, emit fluorescence between 750 nm and 900 nm, which is in the “tissue optical window”. Cybesin was reported targeting the over-expressed bombesin receptors in cancer cells in animal model and the human prostate cancers over-expressing bombesin receptors. The NIR spectral polarization imaging study reported here demonstrated that Cybesin can be used as a smart optical biomarker and as a prostate cancer receptor targeted contrast agent.
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Yang Pu, W. B. Wang, G. C. Tang, Kexian Liang, S. Achilefu, R. R. Alfano, "Near infrared spectral polarization imaging of prostate cancer tissues using Cybesin: a receptor-targeted contrast agent", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85651G (8 March 2013); doi: 10.1117/12.2000079; https://doi.org/10.1117/12.2000079
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