8 March 2013 Development of quantitative parameters to assess in-vivo optical coherence tomography images of late oral radiation toxicity patients
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Abstract
Late oral radiation toxicity is a common condition occurring in a considerable percentage of head and neck cancer patients after radiation therapy which reduces their quality of life. The current examination of these patients is based on a visual inspection of the surface of the oral cavity; however, it is well known that many of the complications start in the subsurface layers before any superficial manifestation. Considering the currently suboptimal examination techniques, we address this clinical problem by using optical coherence tomography (OCT) to monitor the subsurface oral layers with micron-scale resolution images. A spectral-domain OCT system and a specialized oral imaging probe were designed and built for a clinical study to image late oral radiation toxicity patients. In addition to providing qualitative 2D and 3D images of the subsurface oral layers, quantitative metrics were developed to assess the back-scattering and thickness properties of different layers. Metric derivations are explained and preliminary results from late radiation toxicity patients and healthy volunteers are presented and discussed.
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Bahar Davoudi, Bahar Davoudi, Vani Damodaran, Vani Damodaran, Kostadinka Bizheva, Kostadinka Bizheva, Victor Yang, Victor Yang, Robert Dinniwell, Robert Dinniwell, Wilfred Levin, Wilfred Levin, Alex Vitkin, Alex Vitkin, } "Development of quantitative parameters to assess in-vivo optical coherence tomography images of late oral radiation toxicity patients", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 856525 (8 March 2013); doi: 10.1117/12.2001124; https://doi.org/10.1117/12.2001124
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