8 March 2013 Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries
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The purpose of this study was to investigate the artery dilatation performance of the short-duration heating balloon catheter in cadaver stenotic arteries. We designed a prototype short-duration heating balloon catheter that can heat artery media to around 60 °C in 15−25 s by a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. We performed ex vivo short-duration heating dilatation in the cadaver atherosclerotic femoral arteries (initial percent diameter stenosis was 36-98%), with the maximum balloon temperature of 65±5 °C, laser irradiation duration of 25 s, and balloon dilatation pressure of 3.5 atm. The artery lumen configurations before and after the dilatations were assessed with a commercial IVUS system. After the short-duration heating dilatations, the percent diameter stenosis was reduced below 30% without any artery tears or dissections. We estimated that the artery media temperature was raised to around 60 °C in which plaque thickness was below 0.8 mm by a thermal conduction calculation. The estimated maximum temperature in artery adventitia and surrounding tissue was up to 45 °C. We found that the short-duration heating balloon could sufficiently dilate the cadaver stenotic arteries, without thermal injury in artery adventitia and surroundings.
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Natsumi Shimazaki, Natsumi Shimazaki, Sho Naruse, Sho Naruse, Tsunenori Arai, Tsunenori Arai, Nobuaki Imanishi, Nobuaki Imanishi, Sadakazu Aiso, Sadakazu Aiso, "Laser-driven short-duration heating angioplasty: dilatation performance in cadaver atherosclerotic femoral arteries", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654E (8 March 2013); doi: 10.1117/12.2005432; https://doi.org/10.1117/12.2005432

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