8 March 2013 Near-infrared hyperspectral imaging of atherosclerotic plaque in WHHLMI rabbit artery
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Hyperspectral imaging (HSI) of rabbit atherosclerotic plaque in near-infrared (NIR) range from 1150 to 2400 nm was demonstrated. A method to identify vulnerable plaques that are likely to cause acute coronary events has been required. The object of this study is identifying vulnerable plaques by NIR-HSI for an angioscopic application. In this study, we observed the hyperspectral images of the atherosclerotic plaque in WHHLMI rabbit (atherosclerotic rabbit) artery under simulated angioscopic conditions by NIR-HSI. NIR-HSI system was constructed by a NIR super continuum light and a mercury-cadmium-telluride camera. Spectral absorbance values (log (1/R) data) were obtained in the wavelength range from 1150 to 2400 nm at 10 nm intervals. The hyperspectral images were constructed with spectral angle mapper algorithm. As a result, the detections of atherosclerotic plaque under angioscopic observation conditions were achieved especially in the wavelength around 1200 nm, which corresponds to the second overtone of CH stretching vibration mode. The NIR-HSI was considered to serve as an angioscopic diagnosis technique to identify vulnerable plaques without clamping and saline injection.
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Katsunori Ishii, Katsunori Ishii, Akiko Kitayabu, Akiko Kitayabu, Kota Omiya, Kota Omiya, Norihiro Honda, Norihiro Honda, Kunio Awazu, Kunio Awazu, } "Near-infrared hyperspectral imaging of atherosclerotic plaque in WHHLMI rabbit artery", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85654G (8 March 2013); doi: 10.1117/12.2004598; https://doi.org/10.1117/12.2004598

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