8 March 2013 Radiant energy during infrared neural stimulation at the target structure
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Abstract
Infrared neural stimulation (INS) describes a method, by which an infrared laser is used to stimulate neurons. The major benefit of INS over stimulating neurons with electrical current is its spatial selectivity. To translate the technique into a clinical application it is important to know the energy required to stimulate the neural structure. With this study we provide measurements of the radiant exposure, at the target structure that is required to stimulate the auditory neurons. Flat polished fibers were inserted into scala tympani so that the spiral ganglion was in front of the optical fiber. Angle polished fibers were inserted along scala tympani, and rotating the beveled surface of the fiber allowed the radiation beam to be directed perpendicular to the spiral ganglion. The radiant exposure for stimulation at the modiolus for flat and angle polished fibers averaged 6.78±2.15 mJ/cm2. With the angle polished fibers, a 90º change in the orientation of the optical beam from an orientation that resulted in an INS-evoked maximum response, resulted in a 50% drop in the response amplitude. When the orientation of the beam was changed by 180º, such that it was directed opposite to the orientation with the maxima, minimum response amplitude was observed.
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Claus-Peter Richter, Claus-Peter Richter, Suhrud Rajguru, Suhrud Rajguru, Ryan Stafford, Ryan Stafford, Stuart R. Stock, Stuart R. Stock, } "Radiant energy during infrared neural stimulation at the target structure", Proc. SPIE 8565, Photonic Therapeutics and Diagnostics IX, 85655P (8 March 2013); doi: 10.1117/12.2013849; https://doi.org/10.1117/12.2013849
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