26 February 2013 In vivo performance of photovoltaic subretinal prosthesis
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Proceedings Volume 8567, Ophthalmic Technologies XXIII; 856709 (2013) https://doi.org/10.1117/12.2001750
Event: SPIE BiOS, 2013, San Francisco, California, United States
Abstract
We have developed a photovoltaic retinal prosthesis, in which camera-captured images are projected onto the retina using pulsed near-IR light. Each pixel in the subretinal implant directly converts pulsed light into local electric current to stimulate the nearby inner retinal neurons. 30 μm-thick implants with pixel sizes of 280, 140 and 70 μm were successfully implanted in the subretinal space of wild type (WT, Long-Evans) and degenerate (Royal College of Surgeons, RCS) rats. Optical Coherence Tomography and fluorescein angiography demonstrated normal retinal thickness and healthy vasculature above the implants upon 6 months follow-up. Stimulation with NIR pulses over the implant elicited robust visual evoked potentials (VEP) at safe irradiance levels. Thresholds increased with decreasing pulse duration and pixel size: with 10 ms pulses it went from 0.5 mW/mm2 on 280 μm pixels to 1.1 mW/mm2 on 140 μm pixels, to 2.1 mW/mm2 on 70 μm pixels. Latency of the implant-evoked VEP was at least 30 ms shorter than in response evoked by the visible light, due to lack of phototransduction. Like with the visible light stimulation in normal sighted animals, amplitude of the implant-induced VEP increased logarithmically with peak irradiance and pulse duration. It decreased with increasing frequency similar to the visible light response in the range of 2 - 10 Hz, but decreased slower than the visible light response at 20 - 40 Hz. Modular design of the photovoltaic arrays allows scalability to a large number of pixels, and combined with the ease of implantation, offers a promising approach to restoration of sight in patients blinded by retinal degenerative diseases.
© (2013) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
Yossi Mandel, Yossi Mandel, George Goetz, George Goetz, Daniel Lavinsky, Daniel Lavinsky, Phil Huie, Phil Huie, Keith Mathieson, Keith Mathieson, Lele Wang, Lele Wang, Theodore Kamins, Theodore Kamins, Richard Manivanh, Richard Manivanh, James Harris, James Harris, Daniel Palanker, Daniel Palanker, } "In vivo performance of photovoltaic subretinal prosthesis", Proc. SPIE 8567, Ophthalmic Technologies XXIII, 856709 (26 February 2013); doi: 10.1117/12.2001750; https://doi.org/10.1117/12.2001750
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