13 March 2013 Noninvasive imaging of absolute PpIX concentration distribution in nonmelanoma skin tumors at pre-PDT
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Abstract
Photodynamic Therapy (PDT) has proven to be an effective treatment option for nonmelanoma skin cancers. The ability to quantify the concentration of drug in the treated area is crucial for effective treatment planning as well as predicting outcomes. We utilized spatial frequency domain imaging for quantifying the accurate concentration of protoporphyrin IX (PpIX) in phantoms and in vivo. We correct fluorescence against the effects of native tissue absorption and scattering parameters. First we quantified the absorption and scattering of the tissue non-invasively. Then, we corrected raw fluorescence signal by compensating for optical properties to get the absolute drug concentration. After phantom experiments, we used basal cell carcinoma (BCC) model in Gli mice to determine optical properties and drug concentration in vivo at pre-PDT.
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Ulas Sunar, Ulas Sunar, Daniel Rohrbach, Daniel Rohrbach, Janet Morgan, Janet Morgan, Natalie Zeitouni, Natalie Zeitouni, } "Noninvasive imaging of absolute PpIX concentration distribution in nonmelanoma skin tumors at pre-PDT", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680C (13 March 2013); doi: 10.1117/12.2005078; https://doi.org/10.1117/12.2005078
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