13 March 2013 Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments
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Abstract
Advanced stage ovarian carcinoma is characterized by poor prognosis and peritoneal micronodules that exhibit treatment resistance. This is partially due to interactions between multifocal disease and the tumor microenvironment, which includes tumor endothelial cells (TECs) and extracellular matrix components (ECM). Here we describe the development of a three-dimensional model of ovarian cancer that incorporates TECs and ECM. A comparison of several methodologies to generate endothelialized ovarian micronodules along with a preliminary physical characterization is described. This model will allow for detailed investigation of tumor-stroma interactions and how they impact disease progression and treatment response.
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I. Rizvi, I. Rizvi, S. Anbil, S. Anbil, J. P. Celli, J. P. Celli, N. Alagic, N. Alagic, I. Massodi, I. Massodi, T. Hasan, T. Hasan, } "Modeling stromal determinants of 3D tumor growth to inform PDT-mediated combination treatments", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680H (13 March 2013); doi: 10.1117/12.2010678; https://doi.org/10.1117/12.2010678
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