13 March 2013 Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment
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Abstract
Photosensitizer-conjugated polyacrylamide nanoparticles were prepared for in vivo characterization of the minimally invasive and localized treatment of photodynamic therapy (PDT) on brain tumors. By incorporating a variety of nanoparticle matrixes, choosing methylene blue as a photosensitizer, and targeting the nanoparticle by the use of F3 peptide we have made nanoparticle-based PDT improvements to current PDT efficiency. Quantitative growth patterns were determined through visual observation of the tumorigenic response to various treatments by the use of an animal cranial window model. PDT treatments with methylene blue-polyacrylamide (MB-PAA) nanoparticles produced significant adjournment of tumor growth over control groups, clearly demonstrating the advantages of nanoparticle-based PDT agents for the eradication of local tumors, leading to the potential palliation of the advancing disease.
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Kristen Herrmann, Kristen Herrmann, Yong-Eun Lee Koo, Yong-Eun Lee Koo, Daniel A. Orringer, Daniel A. Orringer, Oren Sagher, Oren Sagher, Martin Philbert, Martin Philbert, Raoul Kopelman, Raoul Kopelman, } "Photodynamic characterization and optimization using multifunctional nanoparticles for brain cancer treatment", Proc. SPIE 8568, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXII, 85680I (13 March 2013); doi: 10.1117/12.2005530; https://doi.org/10.1117/12.2005530
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